Coronavirus: In Cameroon, a chloroquine therapy hailed by French expert becomes state protocol
While debate rages in France over Professor Didier Raoult’s recommendation of a mixture of chloroquine (an antimalarial) and azithromycin (an antibiotic) to treat patients with Covid-19, some African countries have taken it very seriously. Such is the case in Cameroon, which has embraced the French professor’s method of treatment.
Despite having authorised treatment in a very restricted manner for serious cases, France has shown scepticism regarding a dual therapy combining chloroquine (an antimalarial), or its derivative hydroxychloroquine, and azithromycin (an antibiotic used for lung and ENT infections and angina) to treat patients suffering from Covid-19. On April 22, France’s Health Minister Olivier Véran said the most recent publications from clinical studies were not in favour of the dual therapy. Six days later, during a speech on France’s strategy for lifting its Covid-19 lockdown, Prime Minister Édouard Philippe clearly reaffirmed the government’s position: “To date, no treatment has proven effective.”
Although the country increased its knowledge of epidemics following the appearance of Ebola in the region, its medical capacities remain limited and a European-style scenario, with a multiplication of serious Covid-19 cases, could lead to a catastrophe. In mid-March, as the epidemic began to spread across Cameroon and European countries, already hard hit, launched lockdown plans, the first video of Raoult selling the effectiveness of his protocol was widely shared on Cameroonian social networks, raising great hopes. In a country where part of the population still has major difficulties in accessing healthcare, the prospect of a treatment based on accessible, inexpensive and familiar drugs appeared to be a blessing.
A chloroquine treatment
On March 27, in a memorandum from Cameroon’s Ministry of Health, the country’s scientific council proposed the widespread use of chloroquine treatment. Judged “promising”, the treatment could make it possible to reduce viral load and contagiousness, even if the group of scientists acknowledged a “lack of conclusive data”. Finally, the council wished to combine the treatment, as recommended by Raoult, with azithromycin to avoid the risks of secondary infections. On April 9, the protocol was validated for the management of all types of patients with positive Covid-19 tests, from asymptomatic cases to patients suffering from severe infections.
“With the arrival of the first cases, the clinicians were tempted to try the protocols themselves, and it was necessary to give clear instructions quickly to organise the response,” explained Dr Alain Etoundi, director of the fight against disease, epidemics and pandemics at Cameroon’s Ministry of Health, to FRANCE 24.
“The question of the supposed toxicity of chloroquine has been addressed and dismissed by the council. So far, the results that are coming to us seem satisfactory, but the evaluation of the treatment is ongoing,” he said.
A ‘national hero’
Professor William Ngatchou is a cardiovascular surgeon at the General Hospital in Douala, the economic capital of Cameroon. When FRANCE 24 asked him if he had heard of Professor Raoult, he responded with amusement: “Everyone knows Professor Raoult in Cameroon! Some even consider him like a national hero.” Like many health professionals in the country, Ngatchou thinks that the effectiveness of dual therapy combining an antimalarial and an antibiotic has been proven: “It’s been almost two months that this protocol has been in use for patients with Covid-19. I myself have noticed significant improvements in patients with its use, and the debate about the side effects of chloroquine seems very exaggerated to me.”
Seven weeks after the detection of the first Covid-19 case on Cameroonian soil, there are more than 2,050 confirmed cases in the country. The progress of the virus seems, as in many African countries, to be much slower than indicated by scientific modelling. Nevertheless, Etoundi asserted that treatment is only one element of a global health policy and it is far too early to claim victory: “We are in a phase where the disease is on the rise and the peak has not yet been reached. Anything is still possible.”
Supply problems and a black market explosion
Beyond a public health resolution, the choice of dual therapy represents a logistical challenge in Cameroon. For while chloroquine was massively used in the country at one time, it has been several decades since it lost its effectiveness in the fight against malaria and was replaced by other, more effective drugs. “Stocks were totally exhausted, we had to place large orders abroad and restart national industrial production,” explained Etoundi.
In Cameroon, public hospitals have been selected to centralise Covid-19 patients. In theory, stocks of chloroquine and azithromycin are sufficient there, although a source within medical services, contacted by FRANCE 24, reported occasional shortages. But the situation is more complex in the pharmaceutical sector. Private pharmacies, very important in Cameroon, sometimes play the role of doctor, and they are not authorized to sell chloroquine.
“As soon as we started talking about the disease in March, a lot of people wanted to buy stocks of chloroquine from us, some aggressively. Others came to try to sell us some,” a pharmacist in a working-class neighbourhood in Douala told FRANCE 24. “Here, demand for the Covid treatment is exploding, we quadrupled our sales of azithromycin between March and April. Since we don’t have chloroquine, customers have switched to similar antimalarial drugs like Artequin, which is already out of stock at wholesalers,” she said.
The black market for drugs, already flourishing in normal times in Cameroon, is on the rise with the Covid-19 crisis. The authorities have already issued several alerts about the circulation of fake chloroquine within the health network.
Finally, another subject that worries the government is the disappearance of hydroxychloroquine, the chloroquine derivative, also recommended by Professor Raoult. It was previously sold over the counter in pharmacies and was very little used, because it was reserved for the treatment of specific diseases such as rheumatoid arthritis and lupus. “The shelves have been robbed very quickly, yet patients depend on these drugs. They now find themselves destitute and we must find solutions to protect them,” Etoundi said.

This article is a translation of the original in French as reported by France 24






!['I want to ask them: 'You guys, you are fighting for separation, but instead you demand money from your brothers? How will we all live together in a new country when you do this?'.' said Kelly. [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/0beafeff0142499ca138ad4cc5e6c6e2_8.jpg)
![Heavily pregnant Alliance went into labour and gave birth to twins during the violence. 'I asked God: How could you give me twins in these times of conflict?' I did not know I could live like this, even for a week,' the 36-year-old said. She was not able to breastfeed at night with the lights on as that would be dangerous as warring parties were fighting outside. [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/cf124669dd894d10afb9d4fc63e28269_8.jpg)
!['When we fled I managed to bring with me some mesh and hair extensions. I thought it would be useful so I could work in Bamenda as well. But when we arrived here we had nothing to protect us from the cold concrete floors, so I had to use them for my twins to sleep on. They were damaged by baby pee,' Alliance said. [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/311e26a6ed9a489dbc4a8849a7e83b6d_8.jpg)
![The scars of war are deep in Alliance's young children. 'When my children hear gunshots, they start to cry and run inside the house and they wet themselves. I lift them up and I carry them, I tell them it will be over soon,' she said. [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/72653b58d83147348128784b3115267a_8.jpg)
![It was May 2018 when 71-year-old Celine escaped her village with her bedridden son, her frail mother, daughter and her three grandchildren. 'On the day we fled, there were heavy clashes and people ran into the bush to hide from the shooting. I could not run with them. My son is bedridden. My mother is nearly 100 years old. I had to stay behind. The army entered our house and asked me: 'Why are you still here?'. I showed them my son and my mother.' [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/9d28a6e8f1e044fd83dd6cadfdddb1bc_8.jpg)
![Two years ago, life changed forever for 28-year-old Alpha when the conflict reached her village of Belo and took the life of her husband. 'One day the shooting got really close and our neighbours told us to quickly lock the house and hide. We did, but men in khakis broke in and dragged my husband out of the house and took him away. My kids and I ran for our lives. The next day someone found my husband dead along the roadside and asked us to come and collect him. When we dared to go back to the house, we found it burnt down to the ground. We lost everything. All our ID cards. Everything.' [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/6f55dcaff0dc4fe8a342337a231346e6_8.jpg)
![Family members Carine, Happiness and Larissa are making the local speciality 'puff-puffs'. The women will sell these at the local market to get some income for the full family of 15 persons. After being displaced by violence, they all share one room that they rent in Bamenda. 'They killed nine people in the market square that morning we fled. I managed to bring with me a bucket of tomatoes and crayfish that I sold the next morning to get some money. I also brought some clothes, our IDs and my family photos. The military burned down our house and my shop,' Happiness said. [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/37470e133fca45739addb4587a405813_8.jpg)
!['Life is not going anywhere,' says Glory, 28. She fled intense fighting in Ndu in January last year with her four children, her younger brother and her husband. With the daily shootings and burning of houses, life was no longer bearable in her village. As far as she knows, their house is still among those standing, but it is too unsafe to go back. So they rent a room in Bamenda with seven family members sharing one mattress. Back in the village, Glory used to roast fish and sell it along the road. Her husband worked as a driver. With barely any income, she finds it difficult to start up a business again. Most of the money they earn goes to rent and food, and most days, they go to bed hungry. School fees are too high to be able to afford them. 'It is really very difficult here,' she said. [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/77c83afad92b4133abdd8861c33270ea_8.jpg)
![The road leading from the small airport outside Bamenda into the city has been the site of intense fighting and the area is mostly abandoned. Burned-out cars and destroyed houses are peppered everywhere. In the two English-speaking regions, more than 250 villages have been burned down and are now fully or partially deserted. [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/32de70c6a5e34e5eb75cb6588229f524_8.jpg)
![''The boys, sometimes they want money, sometimes they just want to kill those they suspect do not support their cause,' says Reverend Mokake in the Cameroon Baptist Convention in Bamenda. 'It has been a hard year. We lost five pastors the last years as a result of the escalation of the conflict.' [Ingebjorg Karstad/NRC]](https://www.aljazeera.com/mritems/Images/2020/4/29/c001e2e1979847ea819020b1eae6f3c8_8.jpg)





