Holders Bayern Munich will take on last year’s beaten finalists Paris Saint-Germain in the Champions League quarter-finals while record 13-time winners Real Madrid meet Liverpool in a repeat of the 2018 final.
The draw also pitted Premier League leaders Manchester City against Borussia Dortmund, with Chelsea set to play Porto in the other tie.
Bayern defeated PSG 1-0 behind closed doors in Lisbon last August to win their sixth European Cup and remain the team to beat in Europe, having won 18 and drawn one of their 19 games in the Champions League since the beginning of last season.
The first leg is set to be played in Germany on April 6 or 7, with the return in Paris a week later.
Meanwhile, the meeting of Jurgen Klopp’s Liverpool and Real is another re-run of a recent final, with the Spaniards beating the Reds 3-1 in Kiev in 2018 to win the last of their record 13 titles to date.
Liverpool bounced back from that to lift the trophy for the sixth time in Madrid in 2019.
Klopp’s side are due to be away from home in the first leg, but it remains to be seen where that match will be played.
Atletico Madrid’s home leg against Chelsea in the last 16 ended up being moved to the Romanian capital Bucharest due to restrictions imposed on travel to Spain by British authorities.
The winner between Liverpool and Real will go onto a semi-final against either Chelsea or Porto, throwing up the possibility of an all-English last-four tie.
Liverpool beat Chelsea in the semi-finals in 2005 and again in 2007.
Unbeaten in 13 games since the appointment of Thomas Tuchel as coach in late January, Chelsea will be expected to get the better of Portuguese champions Porto, who ousted Juventus in the last 16.
However, that tie could also be relocated given travel restrictions between the United Kingdom and Portgual which prompted both legs of last month’s Europa League clash between Arsenal and Benfica to be played at neutral venues, in Italy and Greece.
Meanwhile City will be strong favourites against Dortmund, with the winner of that tie going through to a semi-final showdown with either Bayern or PSG.
Travel restrictions between the UK and Germany could also have an impact on City’s tie against Erling Braut Haaland’s Dortmund.
Both legs of City’s last-16 tie against Borussia Moenchengladbach were played in Budapest, as were both legs of Liverpool’s tie against RB Leipzig in the last round.
This season’s semi-finals are due to be played in late April and early May, with the final scheduled for May 29 in Istanbul.